If you live your life in a way that makes you happy, you will inevitably disappoint some people.
This should not be your goal, but it will happen.
There will be times when you have to choose between what others want or expect from you and what you need to do in order to be happy.
Of course there are some relationships within which you will have to compromise and wherein your attention to the needs of others will be required, but beyond these, you have an obligation to yourself to pursue that which brings you joy and fulfillment.
Regrets are largely optional and your goal should be to live your life in such a way that you die with as few regrets as possible.
No one else can do this for you and no one else will choose this for you.
Choose happiness or live with regret.